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Granado Panto-Sonido for LJ-CV/HP TK 1117 and TK 1217 - Cabinet Vision 10 Plus Forum. - Granado Panto-Sonido for LJ-CV/HP TK 1117 and TK 1217 - Cabinet Vision 10 Plus Forum..[Comparative studies of the two splicing variants of the adenine nucleotide translocase].

The adenine nucleotide translocase (ANT) is essential for mitochondrial energy homeostasis. Two splicing variants, termed ANT1 and ANT2, have been described, but only few data exist on their relative properties. Therefore, we directly compared the kinetic properties of the two splicing variants ANT1 and ANT2 from the mitochondrial inner membrane. While the ANT1 isoform functioned as a hydrogen ion symporter, the ANT2 functioned as a potassium-proton antiporter, confirming previous data. By using the two pharmacological tools cyanide and azide we could show that also at the cell level the two isoforms have different functions. The two variants were also characterized with respect to their expression pattern in various tissues. As expected, the ANT2 variant was solely expressed in the heart and brain, whereas the ANT1 variant was strongly expressed in all tissues. We speculate that the selective expression of the two isoforms may result from a difference in their regulation.Masjid Al-Oubaa

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